Role of Mitogen-Activated Protein Kinases in Ischemia and Reperfusion Injury
نویسندگان
چکیده
منابع مشابه
Role of mitogen-activated protein kinases in ischemia and reperfusion injury : the good and the bad.
There is growing evidence that multiple mitogen-activated protein (MAP) kinases are activated during ischemia and/or reperfusion and may contribute to the structural and functional changes after myocardial ischemia. A new study by Yue et al1 in this issue of Circulation Research attempts to address the role of MAP kinases in ischemic myocardium and suggests that ERK1/ERK2 is part of a “survival...
متن کاملRole of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation
In solid organ transplantation, ischemia/reperfusion (IR) injury during organ procurement, storage and reperfusion is an unavoidable detrimental event for the graft, as it amplifies graft inflammation and rejection. Intracellular mitogen-activated protein kinase (MAPK) signaling pathways regulate inflammation and cell survival during IR injury. The four best-characterized MAPK subfamilies are t...
متن کاملMitogen-activated protein kinases and retinal ischemia.
PURPOSE Mitogen-activated protein kinases (MAPKs), consisting of three major enzymes-extracellular signal-regulated kinase (ERK), p38, and c-jun N-terminal kinase (JNK)-couple cell-surface receptors to critical regulatory targets and gene transcription. We hypothesized that MAPKs are differentially expressed and have distinct functions after retinal ischemia. METHODS Rats were subjected to re...
متن کاملMitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury.
Lung ischemia-reperfusion (I-R) is an important model of oxidant-mediated acute lung and vascular injury. Heme oxygenase-1 (HO-1) is a cytoprotective gene that is markedly induced by lung I-R injury. HO-1 mRNA is increased in mouse lung after 30 min of lung hilar clamping (ischemia) followed by 2-6 h of unclamping (reperfusion) compared with control mice. In a variety of vascular cell types, HO...
متن کاملMitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion
PURPOSE The aim of the present study was to examine changes in the expression of intracellular signal-transduction pathways, specifically mitogen-activated protein kinases, following retinal ischemia-reperfusion. METHODS Retinal ischemia was induced by elevating the intraocular pressure in porcine eyes, followed by 5, 12, or 20 h of reperfusion. The results were compared to those of the sham-...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2000
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.86.6.607